Abstract:

Objective

To detect the relationship between cyclin D1 expression in breast cancer tissue and axillary lymph node metastasis.

Methods

We labeled 1 012 breast cancer patients treated in Breast Disease Center, General Hospital of PLA in 2014 and detected the expression level of cyclin D1 in postoperative carcinoma tissues using immunohistochemical method. According to the cyclin D1 level, the patients were divided into 5 groups, namely group 1 (cyclin D1 negative), group 2 (cyclin D1≥1% and ＜25%), group 3(cyclin D1≥25% and ＜50%), group 4 (cyclin D1≥50% and ＜75%) and group 5 (cyclin D1≥75%).Ninety cases were randomized as subjects in each group and their lymph node status were analyzed. The axillary lymph node metastasis rates between groups were compared by χ² test. Pairwise comparison was performed by partition of χ² test.

Results

The rate of ymph node metastasis was 40.0%, 43.3%, 35.6%, 42.2% and 66.7% in groups 1-5 respectively, which showed a significant difference between groups(χ² =21.503,P＜0.001).The rate of lymph node metastasis in group 5 was significantly higher than that in other 4 groups (χ²=12.857, 9.899,17.431,10.841; all P＜0.004).

Conclusion

When the level of cyclin D1 in breast cancer tissue surpasses the reference value (75%), cyclin D1 can be regarded as a predictive factor of axillary lymph node metastasis.

Key words: Breast neoplasms, Cyclin D1, Lymphatic metastasis